Menthol’s ability to chemically trigger the cold-sensitive receptors in the skin is responsible for the well-known cooling sensation it provokes when inhaled, eaten, or applied to the skin. It is similar to capsaicin, the chemical responsible for the spiciness of hot chilis (which stimulates heat sensors, also without causing an actual change in temperature). It is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and lactobacilli.

Menthol’s analgesic properties are mediated through selective activation of κ-opioid receptors. Menthol blocks calcium channels and voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles.

Methol-Crystal Video